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. 2020 Aug 5;13:7719–7733. doi: 10.2147/OTT.S257852

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© 2020 Mi et al.

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12-LOX modulates CCL5 expression in cancer cells through the AKT/NF-κB pathway. (A and B) Inhibition of 12-LOX, p-AKT, or p-p65 decreased CCL5 expression in Eca109 cells. (C and D) 12-LOX overexpression increased CCL5 levels, which were inhibited by treatment with baicalein, LY294002, or CAPE in Kyse150lv cells. (E) Lower mRNA levels for CCL2, CCL5, CCL22, CSF1, VEGF, TGF-β1, and IL-4 in Eca109B cells compared with Eca109 cells. Experimental data were obtained from three independent tests. *P < 0.05; **P < 0.01; ***P < 0.001.

Abbreviation: ns, no significance.