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. 2020 Aug 5;14:3165–3175. doi: 10.2147/DDDT.S250904

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© 2020 Liu et al.

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The effects of juglanin on brain endothelial monolayer permeability are mediated by VEGF. (A) Human bEnd.3 brain microvascular endothelial cells (HBMVECs) were exposed to OGD/R in the presence or absence of juglanin (5 μM). The expression of VEGF and VEGFR2 were measured by Western blot analysis. (B, C) Human bEnd.3 brain microvascular endothelial cells (HBMVECs) were exposed to OGD/R in the presence or absence of juglanin (5 μM) or 10 ng/mL VEGF-A. Brain endothelial permeability and the expression of occludin and ZO-1 (^{#, *, &}P<0.01 vs previous column group).