Figure 4.

DPO treatment mitigated DFP-induced motor dysfunction. A-B) During pre-DFP exposure period (baseline), there were significant differences between the training and test periods in all three groups, in both Rotarod and Horizontal bar tests, suggesting the animals had normal motor function. A) Baseline vs. post-DFP performances on Rotarod test. At 18d post-DFP, DPO-treated and the (naïve) control groups showed significantly longer latency to fall during the test period on the rotarod test when compared to the vehicle-treated DFP exposed group. B) All groups significantly improved their performance on the Horizontal Bar test at 23d post-DFP regardless of the treatments. Data presented as mean ± SEM (n=6-14, ns=non-significant, *p<0.05, **p<0.01, ***p<0.001).