Figure 7.
DFP exposure caused a persistent elevation of ROS and RNS markers at six weeks post-exposure. Representative Western blots of GP91phox, (anti-GSH) glutathiolated protein, iNOS, 3NT, 4-HNE from control, vehicle, and DPO treated groups. B) DFP exposure significantly increased the levels of GP91phox, glutathiolated protein, iNOS, 3NT, 4-HNE when compared to the control. DPO treatment significantly reduced DFP-induced GP91phox and glutathiolated protein levels, but not iNOS, 3NT, and 4-HNE. C) DPO significantly reduced DFP-induced increased extracellular serum nitrite. Data presented as mean ± SEM (n=5-6, *p<0.05, **p<0.01, ***p<0.001 vs. control; ns=non-significant, #p<0.05, ##p<0.01, ###p<0.001 vs. DFP+vehicle).