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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Transplantation. 2020 Nov;104(11):2424–2434. doi: 10.1097/TP.0000000000003151

Figure 1. Time of Initial Detection, MFI, and HLA specificity of de novo DSA in First Time Kidney Transplant Recipients.

Figure 1.

All study participants (n=95) were tested for DSA in serum samples collected during regularly scheduled posttransplant clinic visits with their CTC clinician provider. Sample analysis to detect DSA was performed by The Ohio State University Tissue Typing Laboratory with LABScreen single-antigen class I and II beads. De novo DSA was detected in 24 percent (23/95) of recipients over the first year posttransplant. A) Initial detection of de novo DSA occurred on average 6.0±3.7 months posttransplant. The mean fluorescence intensity (MFI) ± standard deviation of the dominant DSA specificity at the time of initial detection was 5605±3518. 10 recipients had specificity to HLA class II, 7 had specificity to HLA class I, and 6 recipients had specificity to both HLA class I and II. B) MFI of the dominant (highest MFI) DSA specificity at 1 year posttransplant is shown for recipients who had DSA with specificity for HLA class I, HLA class II or both HLA class I and HLA class II (dominant specificity shown for this latter group represents HLA Class I (n=2) or HLA Class II (n=4). Data was censored for recipients that no longer had DSA (n=3) or had graft loss (n=2) by 1-year posttransplant. Graphed data represents geometric mean ± standard error.