Table 2.

Predictive Values and Discriminatory Ability of Pre-Transplant Peripheral Blood Immune Cell Subset Quantity and Ratios with Development of de novo DSA in the First Year Posttransplant.

Immune cell subsets (pretransplant)	AUC statistic (95% confidence interval)	Optimal threshold (based on Youden index)	Sensitivity	Specificity
CXCR5+IFN-γ+CD8+ T cells	0.81 (0.69 - 0.92)	< 3300 cells per million PBMCs	0.93	0.62
Ratio of CXCR5+IFN-γ+CD8+ T cells to combined Th1/Th2 cells	0.76 (0.63 - 0.88)	< 0.3	0.93	0.62
Ratio of IFN-γ+CD8+ T cells to combined Th1/Th2 cells	0.72 (0.60 - 0.83)	< 1.5	0.91	0.43
CXCR5+CD8+ T cells	0.71 (0.57 - 0.85)	< 20,481 cells per million PBMCs	0.81	0.59
IFN-γ+CD8+ T cells	0.70 (0.58 - 0.82)	< 10,365 cells per million PBMCs	0.74	0.63
CD8+ T cells	0.64 (0.51 - 0.78)	< 164,694 cells per million PBMCs	0.83	0.44
CD4+ T cells	0.63 (0.50 - 0.75)	> 523,165 cells per million PBMCs	0.74	0.56
IFN-γ+CD4+ T cells (Th1)	0.59 (0.46 - 0.72)	> 2,296 cells per million PBMCs	0.87	0.35
IL-10+CD4+ T cells	0.58 (0.44 - 0.72)	> 5,909 cells per million PBMCs	0.48	0.74
IL-4+CD4+ T cells (Th2)	0.58 (0.44 - 0.72)	> 6,553 cells per million PBMCs	0.61	0.60
FoxP3+IL-10+CD4+ T cells (Treg)	0.53 (0.39 - 0.66)	> 342 cells per million PBMCs	1.00	0.12
IL-17+CD4+ T cells (Th17)	0.48 (0.34 - 0.63)	> 1,773 cells per million PBMCs	0.22	0.90