Table 3.
Infections in DSA-positive and DSA-negative Primary Kidney Transplant Recipients in the First Year Posttransplant.
| Number of Recipients with Infections (in the first year post transplant) | |||||
|---|---|---|---|---|---|
| All Recipients (n=95) | DSA negative (n=72) | DSA positive (n=23) | P values | ||
| Recipients with Bacterial and/or Viral Infection | 43 (45.3%)a | 29 (40.3%) | 14 (60.9%) | p=0.03 | |
| Recipients with Bacterial Infectione | 25 (26.3%) | 16 (22.2%)b | 9 (39.1%)c | p=0.07 | |
| Infection site | Urinary Tract Infection | 21 (22.1%) 5 with urosepsis | 14 (19.4%) 3 with urosepsis | 7 (30.4%) 2 with urosepsis | p=0.01 |
| Surgical Wound Infection | 6 (6.3%) | 2 (2.8%) | 4 (17.4%) | p=0.03 | |
| C. Diff. Colitis | 3 (3.2%) | 2 (2.8%) | 1 (4.3%) | p=0.57 | |
| Bacteremia (including urosepsis) | 8 (8.4%) | 4 (5.6%) | 4 (17.4%) | p=0.14 | |
| Recipients with Viral Infectionf | 22 (23.2%)d | 15 (20.8%)d | 7 (30.4%) | p=0.54 | |
| Viremia | Symptomatic Viremia | 10 (10.5%) | 7 (9.7%) | 3 (13%) | p=0.70 |
| Asymptomatic Viremia | 13 (13.7%) | 9 (12.5%) | 4 (17.4%) | p=0.51 | |
4 recipients had both viral and bacterial infections (2 DSA-negative and 2 DSA-positive recipients)
3 DSA-negative recipients with multiple bacterial infections
5 DSA-positive recipients with multiple bacterial infections
1 DSA-negative recipient with 1 symptomatic viral infection and 1 asymptomatic viremia
Bacterial pathogens included Enterococcus faecium (17), Escherichia coli (7), Klebsiella pneumonia (4), Staphylococcus aureus (4), Pseudomonas aeruginosa (4), Clostridium difficile (3), Staphylococcus epidermidis (1), Dermabacter hominis (1), and Citrobacter freundii (1).
Viral pathogens included BKV (12), CMV (5), EBV (2), influenza (2), HSV (1), and Varicella zoster (1)