Table 1.

Zebrafish orthologs of human non-syndromic hearing loss genes

Human deafness locus	Human gene	Zebrafish gene(s)	Zebrafish model	Type of mutant	References
DFNA20/26	ACTG1	-	-		(van Wijk et al., 2003; Zhu et al., 2003)
DFNB44	ADCY1	adcy1a, adcy1b	Yes	Morpholino	(Santos-Cortez et al., 2014)
DFNX5	AIFM1	aifm1	-		(Zong et al., 2015)
-	ATP2B2	atp2b2	-		(Smits et al., 2019)
DFNB93	CABP2	cabp2a, cabp2b	-		(Schrauwen et al., 2012)
DFNA44	CCDC50	ccdc50	-		(Modamio-Hoybjor et al., 2007)
DFNB32/105	CDC14A	cdc14aa, cdc14ab	Yes	Morpholino CRISPR	(Delmaghani et al., 2016; Imtiaz et al., 2018)
DFNA66	CD164	cd164	-		(Nyegaard et al., 2015)
DFNB12	CDH23	cadherin-like 23	Yes	ENU Morpholino	(Bork et al., 2001; Nicolson et al., 1998; Söllner et al., 2004)
DFNA4B, DFNB113	CEACAM16	si:dkey-11o1.7	-		(Booth et al., 2018) (Zheng et al., 2011)
DFNB48	CIB2	cib2	Yes	Morpholino	(Riazuddin et al., 2012)
-	CLDN9	-	-		(Sineni et al., 2019)
DFNB29	CLDN14	-	-		(Wilcox et al., 2001)
DFNB103	CLIC5	clic5a, clic5b	-		(Seco et al., 2015)
DFNA9	COCH	coch	-		(Robertson et al., 1998)
DFNX6	COL4A6	col4a6	-		(Rost et al., 2014)
DFNA37	COL11A1	col11a1a, col11a1b	-		(Booth et al., 2019)
DFNB53, DFNA13	COL11A2	col11a2	-		(Chen et al., 2005; McGuirt et al., 1999)
DFNA40	CRYM	crym	-		(Abe et al., 2003)
DFNB66	DCDC2	dcdc2b	Yes	Morpholino	(Grati et al., 2015)
DFNA5	GSDME	dfna5a, dfna5b	Yes	Morpholino	(Busch-Nentwich et al., 2004; Van Laer et al., 1998)
DFNA1	DIAPH1	-	-		(Lynch et al., 1997)
DFNA71	DMXL2	dmxl2	-		(Chen et al., 2017)
DFNB88	ELMOD3	elmod3	-		(Jaworek et al., 2013; Li et al., 2018)
DFNB102	EPS8	eps8a, eps8b	-		(Behlouli et al., 2014)
DFNB106	EPS8L2	eps8l2	-		(Dahmani et al., 2015)
DFNB36	ESPN	espn, espnl	-		(Naz et al., 2004)
DFNB109	ESRP1	esrp1	-		(Rohacek et al., 2017)
DFNB35	ESRRB	esrrb	-		(Collin et al., 2008)
DFNA10	EYA4	eya4	Yes	Morpholino	(Wayne et al., 2001) (Schonberger et al., 2005)
DFNB104	RIPOR2	ripor2	Yes	Morpholino	(Diaz-Horta et al., 2014)
-	FOXF2	foxf2a, foxf2b	-		(Bademci et al., 2019)
DFNB26	GAB1	gab1	Yes	Morpholino	(Yousaf et al., 2018b)
DFNB15/72/95	GIPC3	gipc3	-		(Ain et al., 2007; Charizopoulou et al., 2011; Rehman et al., 2011)
DFNB1A, DFNA3A	GJB2	cx30.3	Yes	Morpholino	(Alvarez et al., 2005; Barashkov et al., 2011; Chang-Chien et al., 2014; Kelsell et al., 1997)
DFNB91, DFNA2B	GJB3	cx35.4	-		(Xia et al., 1998)
DFNB1B, DFNA3B	GJB6	cx30.3	Yes	Morpholino	(Chang-Chien et al., 2014; del Castillo et al., 2002; Grifa et al., 1999)
DFNB82	GPSM2	gpsm2	-		(Yousaf et al., 2018a)
DFNA114	GRAP	grapa, grapb	-		(Li et al., 2019)
DFNA28	GRHL2	grhl2a, grhl2b	Yes	Tol2	(Vona et al., 2013) (Han et al., 2011)
DFNB25	GRXCR1	grxcr1	Yes	CRISPR TALEN	(Blanco-Sánchez et al., 2018; Schraders et al., 2010b)
DFNB101	GRXCR2	-	-		(Imtiaz et al., 2014)
DFNB39	HGF	hgfa, hgfb	-		(Schultz et al., 2009)
DFNA68	HOMER2	homer2	-		(Azaiez et al., 2015)
DFNA2C	IFNLR1	crfb2	Yes	Morpholino	(Gao et al., 2018)
DFNB42	ILDR1	ildra1, ildr1b	Yes	Morpholino	(Borck et al., 2011; Sang et al., 2014)
DFNB89	KARS	kars	-		(Santos-Cortez et al., 2013)
DFNA2A	KCNQ4	kcnq4	-		(Kubisch et al., 1999)
DFNA69	KITLG	kitlga, kitlgb	-		(Zazo Seco et al., 2015)
DFNB66/67	LHFPL5	lhfpl5a, lhfpl5b	Yes	ENU	(Kalay et al., 2006; Obholzer et al., 2012; Shabbir et al., 2006; Tlili et al., 2005)
DFNA7	LMX1A	lmx1aI	-		(Wesdorp et al., 2018a)
DFNB77	LOXHD1	loxhd1a, loxhd1b	-		(Grillet et al., 2009)
-	LRP5	-	-		(Xia et al., 2017)
DFNB63	LRTOMT/COMT2	tomt	Yes	Tol2	(Ahmed et al., 2008b; Du et al., 2008; Erickson et al., 2017)
DFNB49	MARVELD2	marveld2a, marveld2b	-		(Riazuddin et al., 2006a)
DFNA70	MCM2	mcm2	-		(Gao et al., 2015)
DFNB97	MET	met	Yes	Morpholino	(Mujtaba et al., 2015)
DFNM1	METTL13	mettl13	-		(Yousaf et al., 2018b)
DFNA50	MIR96	mir96	-		(Mencia et al., 2009)
DFNB111	MPZL2	mpzl2b	-		(Bademci et al., 2018; Wesdorp et al., 2018b)
DFNB74	MSRB3	msrb3	Yes	Morpholino	(Ahmed et al., 2011; Shen et al., 2015)
DFNA4A	MYH14	myh14	-		(Donaudy et al., 2004)
DFNA17	MYH9	myh9a, myh9b	-		(Lalwani et al., 2000)
DFNB3	MYO15A	myosin XVAa, myosin XVAb	-		(Wang et al., 1998)
DFNB30, DFNA	MYO3A	myosin IIIA	-		(Grati et al., 2016; Walsh et al., 2002)
DFNB37, DFNA22	MYO6	myosin VIa, myosin VIb	Yes	ENU	(Ahmed et al., 2003c; Melchionda et al., 2001; Seiler et al., 2004)
DFNB2, DFNA11	MYO7A, MYO7A	myosin VIIAa, myosin VIIAb	Yes	ENU	(Ernest et al., 2000; Liu et al., 1997a; Wasfy et al., 2014; Weil et al., 1997)
DFNB94	NARS2	nars2	-		(Simon et al., 2015)
DFNA34	NLRP3	-	-		(Nakanishi et al., 2017)
DFNA67	OSBPL2	osbpl2a, osbpl2b	Yes	ENU	(Thoenes et al., 2015; Wang et al., 2019; Xing et al., 2015)
DFNB22	OTOA	-	-		(Zwaenepoel et al., 2002)
DFNB9	OTOF	otoferlin-a, otoferlin-b,	Yes	Morpholino	(Chatterjee et al., 2015; Yasunaga et al., 1999)
DFNB18B	OTOG	otogelin	Yes	ENU	(Schraders et al., 2012) (Stooke-Vaughan et al., 2015)
DFNB84	OTOGL	otogelin-like	Yes	Morpholino	(Yariz et al., 2012)
DFNA41	P2RX2	p2rx2	-		(Yan et al., 2013)
DFNB23	PCDH15	pcdh15a, pcdh15b	Yes	Tol2	(Ahmed et al., 2003a; Seiler et al., 2005)
DFNA74	PDE1C	pde1ca, pde1cb	-		(Wang et al., 2018)
DFNB57	PDZD7	pdzd7a, pdzd7b	Yes	Morpholino	(Ebermann et al., 2010; Schneider et al., 2009)
DFNB59	PJVK	dfnb59	-		(Delmaghani et al., 2006)
-	PLS1	pls1	-		(Schrauwen et al., 2019)
DFNB70	PNPT1	-	-		(von Ameln et al., 2012)
DFNX2 (DFN3)	POU3F4	-	-		(de Kok et al., 1995)
DFNA15	POU4F3	pou4f3	-		(Vahava et al., 1998)
DFNB100	PPIP5K2	ppip5k2	-		(Yousaf et al., 2018a)
DFNX1 (DFN2)	PRPS1	prps1a, prps1b	Yes	Morpholino	(DeSmidt et al., 2019; Liu et al., 2010; Pei et al., 2016)
DFNB84, DFNA73	PTPRQ	ptprq	-		(Eisenberger et al., 2018; Schraders et al., 2010a)
DFNB24	RDX,	moesin a, moesin b	-		(Khan et al., 2007)
DFNA27	REST	rest	-		(Nakano et al., 2018)
DFNB108	ROR1	ror1	-		(Diaz-Horta et al., 2016)
DFNB68	S1PR2	s1pr2	Yes	Morpholino	(Santos-Cortez et al., 2016)
DFNA91	SERPINB6	-	-		(Sirmaci et al., 2010)
DFNA23	SIX1	six1a, six1b	-		(Mosrati et al., 2011)
DFNA25	SLC17A8	slc17a8/vglut3	Yes	Morpholino	(Obholzer et al., 2008; Ruel et al., 2008)
DFNB60	SLC22A4	slc22a4	-		(Ben Said et al., 2016)
DFNB4	SLC26A4	slc26a4	-		(Li et al., 1998)
DFNB61	SLC26A5	slc26a5	-		(Liu et al., 2003)
DFNA64	SMAC/DIABLO	diabloa diablob	-		(Cheng et al., 2011)
DFNX4 (DFN6)	SMPX	smpx	-		(Huebner et al., 2011; Schraders et al., 2011)
-	SPATC1L	-	-		(Morgan et al., 2019)
DFNB115	SPNS2	spns2	-		(Ingham et al., 2019)
DFNB16	STRC	strca strcb	-		(Verpy et al., 2001)
DFNB76	SYNE4	-	-		(Horn et al., 2013)
DFNB86, DFNA65	TBC1D24	tbc1d24	-		(Azaiez et al., 2014; Rehman et al., 2014)
DFNB21, DFNA8/12	TECTA	tecta	Yes	ENU	(Mustapha et al., 1999; Stooke-Vaughan et al., 2015; Verhoeven et al., 1998)
DFNA51	TJP2	tjp2a, tjp2b	-		(Walsh et al., 2010)
DFNB7/11, DFNA36	TMC1	tmc1	-		(Kurima et al., 2002)
DFNB99	TMEM132E	tmem132e	Yes	Morpholino	(Li et al., 2015)
DFNB6	TMIE	tmie	Yes	Morpholino	(Gleason et al., 2009; Naz et al., 2002)
DFNB8/10	TMPRSS3	tmprss3a, tmprss3b	-		(Scott et al., 2001)
-	TMTC2	Tmtc2a, tmtc2b			(Runge et al., 2016)
DFNA56	TNC	tenascin C	-		(Zhao et al., 2013)
-	TOP2B	top2b			(Xia et al., 2019b)
DFNB79	TPRN	tprn	-		(Li et al., 2010; Rehman et al., 2010)
DFNB28	TRIOBP	triobpa triobpb	-		(Riazuddin et al., 2006b; Shahin et al., 2006)
-	TRRAP	trrap	Yes	CRISPR Morpholino	(Xia et al., 2019a)
DFNB98	TSPEAR	tspeara tspearb	-		(Delmaghani et al., 2012)
DFNB18	USH1C	ush1c	Yes	ENU Morpholino	(Ahmed et al., 2002; Ouyang et al., 2002; Phillips et al., 2011)
DFNB107	WBP2	wbp2	-		(Buniello et al., 2016)
DFNA6/14/38	WFS1	wfs1a, wfs1b	-		(Bespalova et al., 2001; Young et al., 2001)
DFNB31	WHRN	dfnb31a, dfn31b	-		(Mburu et al., 2003)