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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Mitochondrion. 2020 Feb 8;52:56–66. doi: 10.1016/j.mito.2020.02.001

Fig. 5.

Fig. 5.

Temozolomide causes a dose- and time-dependent loss of PSD95 puncta in cultured hippocampal neurons. (A) Graph and representative images of dendrites immunolabeled for postsynaptic density-95 (PSD95) depict a dose-dependent reduction in PSD95 puncta after 4 h exposure. (B) The loss of PSD95 is more prominent after 24 h exposure. Dendritic beading (arrows) prevented quantification out to 100 μm from the soma for the 500 μM TMZ dose at 24 h, and therefore was omitted from the analysis. Scale bars, 5 μm. Data are presented as mean ± SEM, **** p < 0.0001, (n = 4 neurons per group). Scale bars, 20 μm. Red, PSD95.