Table 2.
Platelet reactivity in OSA subjects with significant and milder hypoxemia levels a
| Agonist-induced platelet aggregationb | Agonist-induced ATP secretion from plateletsc | |||||
|---|---|---|---|---|---|---|
| ODI < 15 (n=23) | ODI ≥ 15 (n=8) | p value | ODI < 15 (n=23) | ODI ≥ 15 (n=8) | p value | |
| Epinephrine (5μM) | ||||||
| AUC | 117.40 [54.40, 211.95] | 31.80 [25.25, 55.82] | 0.014 | 0.10 [0.00, 1.30] | 0.00 [0.00, 0.10] | 0.107 |
| amp | 51.00 [15.00, 71.50] | 9.00 [8.00, 14.50] | 0.010 | 0.00 [0.00, 0.59] | 0.00 [0.00, 0.00] | 0.022 |
| rate | 51.00 [27.00, 65.50] | 20.00 [16.00, 29.75] | 0.019 | 4.00 [2.00, 21.00] | 2.00 [2.00, 2.00] | 0.014 |
| Thrombin (1U/ml) | ||||||
| AUC | 443.25 [433.50, 491.17] | 382.65 [277.52, 432.09] | 0.020 | 2.70 [2.27, 4.15] | 2.62 [2.14, 4.40] | 0.857 |
| amp | 101.00 [98.50, 108.75] | 95.00 [70.12, 98.00] | 0.024 | 0.80 [0.65, 1.10] | 0.90 [0.60, 1.30] | 0.769 |
| rate | 383.00 [343.25, 400.75] | 351.00 [255.00, 375.88] | 0.142 | 70.00 [52.00, 85.50] | 76.00 [72.00, 101.38] | 0.250 |
| Collagen (5μg/ml) | ||||||
| AUC | 434.30 [396.75, 462.40] | 463.35 [423.50, 476.85] | 0.362 | 3.10 [2.30, 4.35] | 3.80 [3.25, 4.38] | 0.443 |
| amp | 72.00 [61.00, 79.00] | 66.50 [50.50, 71.75] | 0.556 | 0.78 [0.60, 0.98] | 0.91 [0.80, 1.04] | 0.377 |
| rate | 121.00 [105.50, 135.00] | 132.00 [120.00, 137.25] | 0.470 | 29.00 [17.50, 42.00] | 46.00 [31.75, 54.50] | 0.114 |
| PAR1 (50μM) | ||||||
| AUC | 309.00 [113.17, 333.65] | 328.50 [308.23, 346.01] | 0.275 | 1.50 [0.15, 2.95] | 1.60 [0.97, 3.45] | 0.650 |
| amp | 75.00 [44.00, 81.50] | 77.00 [72.75, 81.25] | 0.299 | 0.47 [0.07, 0.98] | 0.61 [0.42, 1.18] | 0.415 |
| rate | 127.00 [74.50, 143.00] | 129.00 [100.00, 151.12] | 0.572 | 30.00 [6.25, 49.50] | 34.00 [27.50, 68.88] | 0.456 |
| ADP (5μM) | ||||||
| AUC | 408.20 [347.00, 448.75] | 385.10 [242.50, 419.93 | 0.437 | 0.90 [0.20, 2.00] | 0.50 [0.18, 1.30] | 0.353 |
| amp | 72.00 [61.00, 79.00] | 66.50 [50.50, 71.75] | 0.354 | 0.24 [0.00, 0.46] | 0.09 [0.00, 0.33] | 0.376 |
| rate | 108.00 [99.00, 121.00] | 100.00 [94.50, 106.75] | 0.278 | 4.00 [4.00, 8.00] | 4.00 [3.50, 6.25] | 0.662 |
ODI, oxygen desaturation index; PAR1, PAR1-activating hexapeptide (SFLLRN) agonist; ADP, adenosine diphosphate.
a
Values are expressed as median [25th, 75th percentile]. P value from non-parametric Wilcoxon rank-sum test (Mann-Whitney U test).
b
AUC, area under the curve (%*min); amp, amplitude (%); rate, rate (slope) (%/min).
c
AUC, area under the curve (nanomoles*min); amp, amplitude (nanomoles); rate, rate (slope) (nanomoles/min).