Table 4.

Linear regression analysis of association with epinephrine- and thrombin-induced platelet aggregation and secretion

	Epinephrine-induced platelet aggregation a Coef [95% CI]; p value c			Epinephrine-induced ATP secretion b Coef d
ODI ≥15 (ref ODI <15)	AUC	Amp	Rate	AUC	Amp	Rate
Univariate	−86.73 [−149.8,−23.7] p=0.009	−30.82 [−52.2,−9.4] p=0.006	−22.6 [−39.6,−5.6] p=0.011	−0.63	−0.29	−9.56
Adjusted for BMI & BP	−58.37 [−133.7,16.9] p=0.123	−24.8 [−51.6,2] p=0.069	−22.49 [−43.5,−15] p=0.037	−0.61	−0.3	−9.89
Adjusted for fasting glucose & HDL	−82.46 [−173.8,8.8] p=0.075	−32.7 [−63.2,−2.2] p=0.036	−24.61 [−51.2,1.9] p=0.068	−0.36	−0.22	−7.17
Adjusted for BMI, BP, fasting glucose & HDL	−62.06 [−162.8,38.7] p=0.213	−30.04 [−65.5,5.4] p=0.092	−19.53 [−49.7,10.6] p=0.191	−0.35	−0.24	−8.42
	Thrombin-induced platelet aggregation a Coef [95% CI]; p value c or Coef d			Thrombin-induced ATP secretion b Coef [95% CI]; p value c or Coef d
ODI ≥15 (ref ODI <15)	AUC	Amp	Rate	AUC	Amp	Rate
Univariate	−90.51 [−171.9,−9.1] p=0.03	−14.27 [−28.7,0.1] p=0.052	−59.07 [−128.5,10.4] p=0.092	0.03	0.06	12.98
Adjusted for BMI & BP	−41.39 [−121.8,39] p=0.298	−3.35 [−15.7,9] p=0.58	−15.41 [−76.2,45.4] p=0.605	−0.64	−0.1	−0.31 [−30.1,29.5] p=0.983
Adjusted for fasting glucose & HDL	−21.96	−579	−36.32	0.17	0.07	11.85
Adjusted for BMI, BP, fasting glucose & HDL	44.35 [−56.9,145.7] p=0.371	7.9	28.23	−0.64	−0.14 [−0.8,0.5] p=0.648	2.52 [−41.8,46.8] p=0.907

ODI, oxygen desaturation index; Coef, coefficient; CI, confidence interval; BMI, body mass index; BP, blood pressure; HDL, high-density lipoprotein cholesterol.

Coef indicates the mean change in outcome variable among ODI ≥15 vs. ODI <15 in crude unadjusted and adjusted models, where adjustment is done by adding BMI and BP, fasting glucose and HDL cholesterol, or all 4 factors to the model.

^aAUC, area under the curve (%*min); amp, amplitude (%); rate, rate (slope) (%/min).

^bAUC, area under the curve (nanomoles*min); amp, amplitude (nanomoles); rate, rate (slope) (nanomoles/min).

^cIn cases where non-normality of residuals was not detected, coefficient and inference are both valid and shown.

^dIn cases where non-normality of residuals was detected, only coefficient is valid and shown.