Table 1:
Summary of cerebellar stimulation studies in animal models of epilepsy. Abbreviations: pw = pulse width.
| Study | Target | Number of patients | Stimulation protocols | Outcome |
|---|---|---|---|---|
| Bidzinski et. al, 1982 | Hemispheres | 14 | 1–7V; 10Hz; 1msec pw; 30min-1hr duration | 5 patients seizure free, 6 patients with reduced seizures, 2 patients with slight improvement, 1 patient with no change |
| Chkhenkeli et. al, 2004 | Dentate nucleus | 54 | 6–8mA; 50–100Hz; 2msec pw; 10sec epochs | >50% reduction in seizures |
| Cooper et. al, 1973 | Cerebellar cortex | 32 | 1msec pw; other parameters not reported | Over half of patients had >50% reduction in seizure frequency |
| Davis et. al, 1983 | Midline cerebellar cortex | 32 | 10–180Hz; other parameters not reported | 19 patients seizure free, 8 patients with reduced seizures, 4 patients with no change, 1 patient with increased seizures |
| Davis et. al, 1992 | Midline cerebellar cortex | 30 | 1–1.4mA; 150Hz; 0.5msec pw | >50% patients seizure free |
| Gilman et. al, 1977 | Anterior lobe, hemispheres | 6 | 10Hz; 1msec pw | 5 patients with reduced seizures |
| Klun et, al, 1987 | Hemispheres | 6 | 5–50Hz; 0.6msec pw | 3 patients seizure free, 3 patients with reduced seizures |
| Levy et. al, 1979 | Not given | 6 | 3–10V; 10Hz | 3 patients with reduced seizures, 2 patients with no change, 1 patient with increased seizures |
| Sramka et. al, 1976 | Dentate nucleus | 4 | 10V; 10 or 100Hz; 1msec pw; 3 min duration | Temporary improvement |
| Van Buren et. al, 1978 | Cerebellar cortex | 5 | Range | No change |
| Velasco et. al, 2005 | Midline cerebellar cortex | 5 | 3.8mA; 10Hz; 0.45msec pw | 41% mean decrease in seizure frequency |
| Wright et. al, 1984 | Cerebellar cortex | 12 | 7mA; 10Hz | No change |