Table 3:
Summary of optogenetic interventions targeting the cerebellum in animal models of epilepsy.
| Study | Target | Epilepsy model | Stimulation protocols | Opsin, targeting | Animal model | Results |
|---|---|---|---|---|---|---|
| Krook-Magnuson et. al, 2014 | Vermis, simplex lobules IV/V | Intrahippocampal kainate (chronic phase) | 7Hz, 1Hz; 3sec duration | ChR in parvalbumin expressing neurons, Purkinje cells | Mouse | Seizure inhibition with all parameters |
| Krook-Magnuson et. al, 2014 | Vermis, simplex lobules IV/V | Intrahippocampal kainate (chronic phase) | 7Hz, 1Hz; 3sec duration | HR in parvalbumin expressing neurons, Purkinje cells | Mouse | Seizure inhibition with all parameters |
| Streng et. al, 2019 | Fastigial nucleus | Intrahippocampal kainate (chronic phase) | 1Hz, 7Hz, 10Hz; 3sec duration or single 50msec pulse | HR in VGluT2-expresisng neurons | Mouse | No effect |
| Streng et. al, 2019 | Fastigial nucleus | Intrahippocampal kainate (chronic phase) | 1Hz, 7Hz, 10Hz; 3sec duration or single 50msec pulse | ChR in VGluT2-expresisng neurons | Mouse | Seizure inhibition with all parameters |
| Kros et. al, 2015 | Medial and lateral deep cerebellar nuclei | tottering (tg) | Single 30–300msec pulse | ChR2 under hSyn promoter | Mouse | Seizure inhibition with all parameters |
| Kros et. al, 2015 | Medial and lateral deep cerebellar nuclei | C3h/HeOuJ | Single 30–300msec pulse | ChR2 under hSyn promoter | Mouse | Seizure inhibition with all parameters |