Table 3.
Correlation coefficients among fatigue, physical function and inflammation at 3 months
| Fatigue* | 6MWD (meters) | Chair Stand (times) | Arm Curl (times) | Hand Grip (lbs) | |
|---|---|---|---|---|---|
| CRP (pg/ml) | 0.468 (0.021) | −0.467 (0.108) | −0.522 (0.067) |
−0.621
(0.023) |
−0.286 (0.344) |
| IL1ra (pg/ml) | 0.109 (0.611) | −0.396 (0.181) | −0.688 (0.009) |
−0.682
(0.010) |
−0.231 (0.448) |
| IL6 (pg/ml) | 0.298 (0.167) | −0.741 (0.006) | −0.662 (0.019) |
−0.676
(0.016) |
−0.497 (0.101) |
| IL10 (pg/ml) | 0.173 (0.420) | −0.374 (0.209) | −0.779 (0.002) |
−0.899
(<0.001) |
−0.379 (0.201) |
| TNFα (pg/ml) | 0.394 (0.057) | −0.516 (0.071) | −0.588 (0.034) |
−0.666
(0.013) |
−0.099 (0.748) |
| sTNFR2 (pg/ml) | 0.172 (0.421) | −0.505 (0.078) | −0.522 (0.067) |
−0.724
(0.005) |
−0.445 (0.128) |
| MCP1 (pg/ml) | 0.321 (0.126) | −0.165 (0.590) | −0.307 (0.308) | −0.455 (0.118) |
−0.033 (0.915) |
| Fatigue | − | −0.335 (0.264) | −0.488 (0.091) | −0.420 (0.153) |
−0.440 (0.133) |
Note: N=24 for fatigue (missing inflammatory cytokines in two patients); N=13 for physical functions (Physical function tests were added later into the study, only a subset of participants had the physical function tests, plus 4 missing for intervention group). Parenthesis is the p value. These bold values are statistically significant (p<0.05). 6MWD= 6-minute walk distance, CRP = C-reactive protein, IL1ra = interleukin 1 receptor antagonist, IL6 = interleukin 6, MCP1= monocyte chemoattractant protein 1, sTNFR2 = soluble tumor necrosis factor receptor 2, TNFα = tumor necrosis factor α.
*
Fatigue was measured by using Multidimensional Fatigue Inventory-20