Table 2.

Mean differences in enduring effects of 5-MeO-DMT use as function of whether respondents employed each benefit enhancement strategy among the subset of respondents who used 5-MeO-DMT only once in their lifetime (n=116).

	Personally Meaningful				Spiritually Significant				Change in sense of well-being
Strategy	Used	Didn’t Use	t-score	d	Used	Didn’t Use	t-score	d	Used	Didn’t Use	t-score	d
Focus on Intentions	5.3(1.5)	4.8(1.9)	1.60	0.32	3.6(1.2)	3.1(1.6)	1.86	0.37	2.1(1.1)	1.6(1.3)	2.10	0.39
Utilize Ceremonial or Shamanic Techniques	5.7(1.0)	4.8(1.9)	3.36**	0.64	3.9(1.0)	3.2(1.5)	3.34**	0.63	2.4(0.9)	1.7(1.3)	3.46**	0.66
Prepare a safe space	5.2(1.6)	5.0(1.8)	0.73	0.16	3.6(1.3)	3.3(1.6)	1.00	0.22	2.0(1.2)	1.7(1.3)	1.23	0.27
Prepare music for session	4.9(1.8)	5.3(1.5)	−1.35	0.27	3.3(1.4)	3.6(1.4)	−1.15	0.23	1.9(1.2)	2.0(1.2)	−0.79	0.16
Prepare a comfortable place	5.2(1.6)	5.2(1.8)	−0.15	0.04	3.5(1.4)	3.6(1.4)	−0.44	0.10	2.0(1.2)	2.0(1.3)	−0.01	0.00
No distractions	5.2(1.6)	5.0(1.8)	0.75	0.15	3.5(1.4)	3.5(1.2)	−0.29	0.06	2.0(1.2)	1.8(1.2)	0.89	0.18
Use with a guide	5.3(1.4)	5.0(1.9)	0.97	0.18	3.8(1.0)	3.1(1.6)	2.79**	0.53	2.2(1.0)	1.6(1.3)	2.79**	0.53
Use with friends	4.8(1.7)	5.5(1.5)	−2.39**	0.45	3.1(1.5)	3.9(1.1)	3.11**	0.58	1.9(1.2)	2.1(1.2)	−0.85	0.16
Obtain from trusted source	5.1(1.6)	5.5(1.6)	−1.27	0.29	3.4(1.3)	3.7(1.4)	−0.95	0.22	1.9(1.2)	2.0(1.2)	−0.39	0.09
Meditate prior to session	5.6(1.4)	4.8(1.8)	2.71**	0.51	3.8(1.1)	3.2(1.5)	2.85**	0.54	2.5(0.8)	1.5(1.3)	5.34***	1.00
Abstain from sex prior to session	5.5(1.5)	5.1(1.7)	1.05	0.27	3.8(1.5)	3.4(1.3)	1.29	0.33	2.4(1.0)	1.9(1.2)	1.87	0.47
Abstain from alcohol and other substances	5.5(1.5)	4.6(1.8)	2.90**	0.57	3.6(1.4)	3.2(1.2)	1.56	0.30	2.1(1.2)	1.8(1.2)	1.16	0.23
Have a friend I can talk to for integration	5.2(1.5)	5.2(1.8)	0.08	0.02	3.5(1.2)	3.4(1.5)	0.43	0.08	2.1(1.1)	1.8(1.3)	1.51	0.28
Write after session	5.5(1.5)	5.0(1.7)	1.70	0.33	3.8(1.2)	3.3(1.4)	2.11*	0.41	2.2(1.1)	1.8(1.2)	1.93	0.38

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