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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Brain Behav Immun. 2020 Apr 23;88:619–630. doi: 10.1016/j.bbi.2020.04.061

Figure 5. Levels of dopaminergic and immune proteins are altered in the striatum of newborn offspring in a BIR-dependent manner that correlates with repetitive behavioral deficits.

Figure 5.

(A) Representative western blot showing increased MEF2, STAT3, and TH protein from striatum of MIA offspring compared to saline control offspring in a manner dependent on BIR of the dams. Each column is from one animal. (B-D) Densitometry shows increased levels of MEF2A (B), STAT3 (C), and TH (D) protein in MIA offspring relative to saline when normalized to β-tubulin loading controls (MEF2A: F3,24 = 3.968, P < 0.05; STAT3: F3,24 = 6.401, P < 0.01; TH: F3,24 = 3.668, P < 0.05). Data were averaged from two males per litter and 6-7 litters per BIR group; each point indicates the litter average value normalized to controls. Bars represent mean ± s.e.m *p < 0.05, **p < 0.01, ***p < 0.001.