The heatmap shows differential abundance of proteins in EVs produced by H. capsulatum yeast cells cultivated in distinct media. Proteins were grouped based on function. Group 1: Amino acid transport, TCA cycle, intracellular protein transport, phospholipid translocation, and translation. Group 2: DNA repair, lipid metabolism, endocytosis, and mRNA splicing. Group 3: Transcription regulators and protein folding. Group 4: Carbohydrate and polysaccharide metabolism