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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: J Colloid Interface Sci. 2020 May 26;577:406–418. doi: 10.1016/j.jcis.2020.05.088

Figure 5: Atomic force microscopy nanoindentation of platelet poor plasma (PPP) clots reveals increased clot stiffness in clots incorporated with PLPs.

Figure 5:

Clots formed from recalcified PPP in the absence (normal conditions) or presence of an anti-factor IX (fIX) antibody (hemophilia conditions) +/− the addition of 0.5 mg/mL PLPs were analyzed via AFM nanoindentation to determine clot stiffness 16 hours after initial clot polymerization. Both normal and structurally deficient hemophilia-like clots exhibit significantly greater stiffness in the presence of PLPs when compared to normal or hemophilia-like control clots, respectively. n = 3–4 clots per group; 3 locations imaged per clot; 256 forcemaps per location. Individual data and means ± standard deviations are represented for each group. *p < 0.05; **p < 0.01; ****p < 0.0001.