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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Semin Cancer Biol. 2020 Feb 7;68:209–229. doi: 10.1016/j.semcancer.2020.02.003

Figure 1. On-target and off-target based drug repurposing.

Figure 1.

A. Cartoon illustrating the repurposing of drugs (A; B) for different cancers based on their intended targets A and B playing a functional role in cancer. The initial indication may be another cancer or a cancer-unrelated disease. B. Cartoon illustrating the repurposing of a multi-targeted drug (C) for a specific type of cancer based on inhibition of an off-target (G) that plays a functional role in that cancer. The initial indication may be another cancer or a cancer-unrelated disease.