Table 1.
Participants’ Demographics and Behavioral Features
| Demographics and Behavioral Features | PREVENT-AD (n = 115) | DIAN (n = 117) |
|---|---|---|
| Age, Years | 67.6 ± 5.0 (58.6 to 83.3) | 34.6 ± 9.4 (18.0 to 61.0) |
| Estimated Years to Onseta | −5.7 ± 7.8 (−20.8 to 16.8) | −12.9 ± 8.0 (−31.5 to 11.8) |
| Gender, F:M, n (%F) | 86:29 (75%) | 64:53 (55%) |
| APOE ε4 Carriers, n (%) | 44 (38%) | 36 (31%) |
| Global Aβ SUVRb | 1.1 ± 0.3 (0.9 to 2.3) | 0.9 ± 0.2 (0.8 to 1.6) |
| Tau Braak I SUVR | 1.1 ± 0.1 (0.7 to 1.7) | - |
| Tau Braak III SUVR | 1.2 ± 0.1 (0.8 to 1.7) | - |
| Tau Braak IV SUVR | 1.1 ± 0.1 (0.9 to 1.6) | - |
| MMSE | 28.8 ± 1.3 (24 to 30) | 29.1 ± 1.2 (24 to 30) |
| Cognitive Lifestyle | ||
| Education, years | 15.0 ± 3.2 (7.0 to 22.0) | 15.2 ± 3.0 (10.0 to 24.0) |
| Lifetime cognitive activity | 2.6 ± 0.7 (1.2 to 4.4) | - |
| Neuropsychiatric Symptoms | ||
| Depression | 1.3 ± 1.9 (0 to 10.0) | 1.5 ± 1.8 (0 to 9.0) |
| Anxiety | 2.1 ± 3.6 (0 to 18.0) | - |
| Stress | 4.7 ± 5.2 (0 to 24.0) | - |
| Apathy | 27.8 ± 6.2 (18.0 to 46.0) | - |
| NPI-Q | - | 0.7 ± 1.8 (0 to 11.0) |
| Personalityc | ||
| Openness | 38.9 ± 6.5 (21.0 to 50.0) | 79.5 ± 11.8(49.0 to 107.0) |
| Neuroticism | 17.6 ± 6.1 (8.0 to 35.0) | 60.1 ± 13.8 (31.0 to 94.0) |
| Conscientiousness | 37.4 ± 5.4 (19.0 to 45.0) | 96.0 ± 12.3 (67.0 to 120.0) |
| Agreeableness | 39.2 ± 4.0 (26.0 to 45.0) | 95.8 ± 10.2 (62.0 to 115.0) |
| Extraversion | 26.7 ± 5.6 (14.0 to 40.0) | 85.6 ± 12.1 (47.0 to 109.0) |
Data presented as mean ± SD (range) unless noted otherwise.
Aβ, amyloid-β; DIAN, Dominant Inherited Alzheimer Network; F, female; M, male; MMSE, Mini-Mental State Evaluation; NPI-Q, Neuropsychiatric Inventory Questionnaire; PREVENT-AD, PRe-symptomatic EValuation of Experimental or Novel Treatments for AD; SUVR, standardized uptake value ratio.
For PREVEN-AD participants, data are sporadic estimated years to onset (data available for 111 participants). For DIAN participants, data are estimated years to onset (age of participant - age of the parent at symptom onset).
[18F]NAV4694 is used in PREVENT-AD and [11C]PIB is used in DIAN.
Personality traits are assessed with the Big Five Inventory in PREVENT-AD and the International Personality Item Pool Representation of the Revised NEO Personality Inventory in DIAN, and the 2 questionnaires have different scales.