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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Eur J Med Chem. 2020 Jun 13;201:112408. doi: 10.1016/j.ejmech.2020.112408

Fig. 1. Unique lipids found in cell envelope of Mtb.

Fig. 1.

All of the molecules shown exist as a suite of related isomers that vary in the lipid chain length. If reported, the major isomer is shown otherwise a representative molecule is depicted. Specific FadDs are responsible for installation of the lipid chains highlighted in blue. A. PDIM A (1) biosynthesis requires FAAL26 and FAAL28 for synthesis of phthiocerol and mycocerosic acid moieties, respectively. B. PGLs (2) require FAAL22 and FAAL29 for assembly of the phenolphthiocerol lipid as well as FAAL28 for the two mycocerosic acids. C. MBTs (3) employ FAAL33 for installation of the C-20 lipid residue on the central lysine moiety. D. Sulfolipids represented by SL-1 (4) require FAAL23 for biosynthesis of the phthioceranic acid and two hydroxyphthioceranic acid groups. E. The mycolic acids represented by the most abundant α-MA (5) employ FAAL32 for introduction of the meromycolic acid subunit.