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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Eur J Med Chem. 2020 Jun 13;201:112408. doi: 10.1016/j.ejmech.2020.112408

Scheme 6.

Scheme 6.

Synthesis of 41a, 38b–56b. Reaction conditions: (a) ArOH, DIAD, PPh3, THF, 65–95%; (b) MsCl, Et3N, THF, 97%; (c) NaH, THF, thiophenol, 98%; (d) 10 mol% CuI, K3PO4·H2O, H2O/decanol, 84%.