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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Eur J Med Chem. 2020 Jun 13;201:112408. doi: 10.1016/j.ejmech.2020.112408

Scheme 8.

Scheme 8.

Synthesis of sulfamate 89. Reaction conditions: (a) LiAlH4, THF, 80%; (b) ClSO2NH2, NaH, THF, 100%; (c) TsCl, DMAP, CH2Cl2, 100%; (d) Cs2CO3, DMF, 22%; (e) 80% aqueous TFA, 97%.