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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Eur J Med Chem. 2020 Jun 13;201:112408. doi: 10.1016/j.ejmech.2020.112408

Scheme 1.

Scheme 1.

Synthesis of acyl sulfamate inhibitors 9 and 13–56. Reaction conditions: (a) N-hydroxysuccinimide, DCC, CH2Cl2; (b) 1 N aqueous NaOH/MeOH, 100 °C, then N-hydroxysuccinimide, EDC, CH2Cl2; (c) Cs2CO3, DMF, 78–93%; (d) 80% aqueous TFA, 18–89%.