Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The enzymatic and antimicrobial activity of linker analogues 83, 89 and 93.
 |
||||
|---|---|---|---|---|
| MIC (μM)a |
Kiapp (μM)b |
Kiapp (μM)c |
||
| Cmpd | R = | GAST | FACL19 | FAAL28 |
| 32 |  |
3.13 | >100 | 0.7 |
| 83 |  |
1.56–3.13 | >100 | 3.1 |
| 89 |  |
>50 | >100 | >100 |
| 93 |  |
>50 | >100 | >100 |
Microbiological and biochemical data is from 3 replicates.
Whole cell inhibitory activity against Mtb H37Rv in GAST medium.
Inhibitory activity against FACL19.
Inhibitory activity against FAAL28.
