Table 1.
Plasma cytokine and chemokine levels 36 hours following peripheral LPS inoculation in control and circadian desynchronized mice.
| Cytokine | Effect of LPS | Direction of effect | Effect of desynchronization | Direction of effect | Interaction |
|---|---|---|---|---|---|
| Eotaxin | p = 0.183, F = 1.87 | ns | p = 0.454, F = 0.58 | ns | p = 0.787, F = 0.07 |
| GM-CSF | p = 0.015, F = 6.79 | ↑ | p = 0.306, F = 1.09 | ns | p = 0.451, F = 0.58 |
| Gro-α/KC | p < 0.001, F = 30.91 | ↑ | p = 0.673, F = 0.18 | ns | p = 0.568, F = 0.33 |
| IFNγ | p = 0.452, F = 0.58 | ns | p = 0.939, F = 0.01 | ns | p = 0.252, F = 1.37 |
| IL-12p70 | p = 0.233, F = 1.49 | ns | p = 0.061, F = 3.82 | ns | p = 0.429, F = 0.65 |
| IL-13 | p = 0.528, F = 0.41 | ns | p = 0.073, F = 3.47 | ns | p = 0.596, F = 0.29 |
| IL-18 | p < 0.001, F = 139.21 | ↑ | p = 0.571, F = 0.33 | ns | p = 0.109, F = 2.75 |
| IL-1β | p < 0.001, F = 21.21 | ↑ | p = 0.775, F = 0.08 | ns | p = 0.094, F = 3.02 |
| IL-2 | p = 0.325, F = 1.01 | ns | p = 0.410, F = 0.70 | ns | p = 0.743, F = 0.11 |
| IL-4 | p = 0.008, F = 8.34 | ↑ | p = 0.704, F = 0.15 | ns | p = 0.728, F = 0.12 |
| IL-5 | p = 0.051, F = 4.16 | ↓ | p = 0.373, F = 0.82 | ns | p = 0.057, F = 3.96 |
| IL-6 | p < 0.001, F = 27.58 | ↑ | p = 0.435, F = 0.63 | ns | p = 0.042, F = 4.56 |
| IP-10 | p < 0.001, F = 166.85 | ↑ | p = 0.166, F = 2.02 | ns | p = 0.865, F = 0.03 |
| MCP-1 | p < 0.001, F = 61.93 | ↑ | p = 0.331, F = 0.98 | ns | p = 0.288, F = 1.18 |
| MCP-3 | p < 0.001, F = 69.35 | ↑ | p = 0.839, F = 0.04 | ns | p = 0.795, F = 0.07 |
| MIP-1α | p < 0.001, F = 51.66 | ↑ | p = 0.624, F = 0.25 | ns | p = 0.651, F = 0.21 |
| MIP-1β | p < 0.001, F = 103.78 | ↑ | p = 0.176, F = 1.93 | ns | p = 0.390, F = 0.76 |
| MIP-2 | p < 0.001, F = 26.01 | ↑ | p = 0.702, F = 0.15 | ns | p = 0.763, F = 0.09 |
| RANTES | p < 0.001, F = 117.39 | ↑ | p = 0.061, F = 3.82 | ns | p = 0.079, F = 3.34 |
| TNFα | p < 0.001, F = 85.79 | ↑ | p = 0.349, F = 0.91 | ns | p = 0.928, F = 0.01 |
Table presents results from plasma cytokine and chemokine multiplex array. Plasma was collected from control or circadian desynchronized mice 36 hours post-inoculation with PBS or LPS. Reported statistics (Two-way ANOVA, with p and F values) summarize main effects of LPS treatment and environmental lighting condition, and the interaction. Bolding indicates a statistically significant main effect or interaction.