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. Author manuscript; available in PMC: 2021 Aug 6.
Published in final edited form as: Cell. 2020 Jun 30;182(3):754–769.e18. doi: 10.1016/j.cell.2020.06.002

Figure 4: Temporal differences in chromatin accessibility at cortical pREs.

Figure 4:

4A) GREAT analysis of functions associated with 14gw-specific pREs from frontal cortex tissues (combined PFC and motor samples).

4B) GREAT analysis of functions associated with 19gw-specific pREs from frontal cortex tissues.

4C) Genes differentially expressed in frontal cortex between 14gw and 19gw are enriched for 14gw- and 19gw-specific pREs and OCRs.

4D,E) ATAC-seq reads from 14gw and 19gw frontal cortex pooled samples. pREs are highlighted in yellow. The nearby genes are differentially expressed at 14gw and 19gw, respectively. Y axis scale is 0 to 50.

4F,G) Effect size and significance of TF motifs enriched in 14gw frontal cortex-specific pREs compared to 19gw-specific pREs, and vice versa.