Table 1.
Summary of RVS results by MAGELLAN and that on the component modules. Data shown are median and average (in parentheses) EF1% values on 224 test Class A GPCRs. P-value is calculated in the Wilcoxon signed-rank test between MAGELLAN and the control modules. Alternative homology constraint cutoff was applied to remove all homologous templates with sequence identity >30%.
| Methods & Modules | With homology cutoff | Without homology cutoff | ||
|---|---|---|---|---|
| EF1% | p-value | EF1% | p-value | |
| MAGELLAN | 14.38 (23.03) | -- | 62.03 (59.13) | -- |
| BindRes | 10.19 (17.90) | 5 × 10−7 | 56.39 (56.35) | 4 × 10−6 |
| BLAST | 7.04 (16.49) | 5 × 10−14 | 53.02 (53.26) | 1 × 10−14 |
| PSI-BLAST | 11.83 (20.79) | 5 × 10−3 | 54.31 (54.18) | 2 × 10−14 |
| TM-align | 13.76 (20.15) | 8 × 10−9 | 56.92 (56.39) | 6 × 10−4 |
| PPS-Align | 10.99 (20.25) | 2 × 10−6 | 56.90 (55.55) | 1 × 10−6 |