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DOA variants linked to certain MHCII genes associated with specific outcomes of HBV infection
| Variant Phenotype (SNP) |
Linked to: Gene (SNP) |
Linkage Disequilibrium D’ |
Associated Viral Phenotype |
|---|---|---|---|
| DOA*0102 Gain of Function (rs11575906 ) | HLA-DPA1 (rs3077 - ‘C’ allele) | 1 (p<0.0001) | HBV Persistence |
| DOα F114L Loss of Function (rs34987694 ) | HLA-DPA1 (rs3077 - ‘T’ allele) | 1 (P<0.0001) | Ab-mediated HBV clearance |
