. Author manuscript; available in PMC: 2021 Aug 1.

Published in final edited form as: J Biol Inorg Chem. 2020 Jun 4;25(5):717–727. doi: 10.1007/s00775-020-01794-z

Table 1.

Inhibition of ZnZn-NDM-1 by the current set of thiol-containing compounds.

	IC₅₀ (μM)^a	K_D (μM)	ΔH (kj/mol)	ΔS (J/K*mol)	thiol pK_a^c
L-captopril	6.4	2.2 ± 1.0	−28.9	12.2	8.5
D,L-thiorphan	1.8	5.0 ± 2.0	−30.6	−1.7	9.6
tiopronin	84	27 ± 1	ND^b	ND^b	8.4
2,3-dimercaprol	1.3	2.6 ± 0.1	ND^b	ND^b

From Klinger et al.[3]

Not determined. See text for details.