Table 1: Demographic Information.

This table shows the demographic information in both the healthy control and MDD groups, including sex assigned at birth, gender identity, age, ethnicity, race, SCID score, PROMIS depression and anxiety scores, and prescription of psychoactive drugs.

Characteristic	Specific Descriptor	Healthy Controls	Major Depressive Disorder
Sex Assigned at Birth	Female	34 (72.3%)	38 (88.4%)
	Male	13 (27.7%)	5 (11.6%)
Age (years)	Mean (SD)	22.1 (1.8)	21.9 (2.1)
Ethnicity	Hispanic	3 (6.4%)	6 (14.0%)
	Non-Hispanic	44 (93.3%)	37 (86.0%)
Race	White	38 (80.1%)	33 (76.7%)
	Black	3 (6.4%)	2 (4.7%)
	Asian	5 (10.6%)	3 (7.0%)
	Multiple	1 (2.1%)	3 (7.0%)
	No Response	0 (0%)	2 (4.7%)
PROMIS Depression Score	Mean (SD)	9.3 (1.4)	25.0 (6.9)
Prescribed Psychoactive Drugs	Single	1 (2.1%)	13 (30.0%)
	Multiple	0 (0%)	15 (34.9%)
	No	46 (97.9%)	15 (34.9%)