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. 2020 Jun 25;94(9):3137–3155. doi: 10.1007/s00204-020-02808-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Concentration-dependent effects on gene expression of the PPAR-responsive genes (ANGPTL4, PDK4, PLIN2, PLIN4, and CPT1A), ADH4, and genes related to cholesterol biosynthesis (LSS, FDPS, HMGCR, EBP, IDI1, and ACAT2) by PFOS, PFOA, and PFNA. Gene expression was normalized to the housekeeping gene RPL27 and the gene expression of the solvent control was set at 1. Treatments with statistically significant difference (p < 0.05) in gene expression compared to the solvent control are indicated with * (one-way ANOVA followed by Dunnett’s multiple comparison test (Graphpad Prism 5). Data presented as mean ± SD of three independent experiments