Figure 3.

The Stability of siRNAs in Human Liver Homogenate Has a Strong Correlation to Their Stability in Mouse Liver Homogenate

(A) The correlation between siRNA stability in mouse liver homogenate and human liver homogenate is comparable to the correlation between cyno and human. This can also be concluded from the strong correlation between siRNA stability in cyno and mouse liver homogenates. Therefore, mouse and cyno liver homogenates appear to be interchangeable for performing the liver stability assay. (B) The findings of (A) were further supported by employing a larger number of siRNAs and confirming the strong correlation between mouse and human liver homogenates for siRNA stability measurement.