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. 2020 Jul 11;10(20):9083–9099. doi: 10.7150/thno.46467

Figure 7.

Figure 7

Selene was specifically enriched in the mitochondria via TLR4/TRAF3/MFN1 pathway. A. Colocalization of MFN1/TRAF3 and TLR4/TRAF3 was analyzed by immunostaining of OVCAR-3 cells and detected using confocal microscopy. B. Colocation of Selene and mitochondria in OVCAR-3 cells after TRAF3 and MFN1 knockdown. C and D. Se content in the whole cells and mitochondria as detected using ICP-MS in TRAF3 and MFN1 knocked down OVCAR-3 cells. E and F. The effect of Selene on OVCAR-3 ascites model when TLR4 and TRAF3 in OVCAR-3 cells were knocked down. G. Results of cell apoptosis detection in the OVCAR-3 ascites model when TLR4 and TRAF3 in OVCAR-3 cells were knocked down. Results are shown as means ± SD (*P < 0.05, **P < 0.01).