Figure 1.

Representative images showing the dynamics of hypoxia resolution during chemoradiation as well as representative immunohistochemical stainings. (A-C) Pre-therapeutic CT (A), MRI (B) and [¹⁸F]FDG PET (C) images showing an oropharyngeal carcinoma with multiple confluent cervical lymph nodes, cT3 cN2c cM0. (D-F) [¹⁸F]FMISO PET at weeks 0 (D), 2 (E) and 5 (F) showing moderate pre-therapeutic hypoxia with a slight decrease during chemoradiation. (G-I) Representative HE staining (G) of the tumor sample as well as pre-therapeutic immunohistochemical staining for PD-1 (H) and PD-L1 (I) demonstrating high expression of PD-L1 and PD-1. 20x objective magnification.