Figure 3.

High PD-1 expression in pre-therapeutic tumor biopsies leads to reduced hypoxia resolution during chemoradiation. (A) SUV index values in weeks 0, 2 and 5 during chemoradiation in dependence of the pre-therapeutic PD-1 expression on immune cells. (B) Hypoxia resolution between weeks 0 and 5 of chemoradiation quantified by ΔSUV index values stratified by PD-1 expression. Columns represent mean values, while error bars show standard deviation. *p<0.05, **p<0.01, unpaired two-sided t-tests.