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. 2020 Jul 11;10(20):8974–8995. doi: 10.7150/thno.44912

Figure 7.

Figure 7

Nrp1 is a direct target of miR-23b-3p in MS-SCs-EVs. Notes: (A) Nrp1 mRNA levels in DRG neurons of each group measured by qRT-PCR (n=4). (B) Nrp1 protein expression in DRG neurons of each group (C) DRGs were stained for β-tubulin III (red) and Nrp1 (green) to demonstrate the Nrp1 protein expression 7 days after addition of MS-SCs-EVs (C1-C3), miR-23b-3p KD MS-SCs-EVs (C4-C6) and SCs-EVs (C7-C9) in the injury site of rats with sciatic nerve injury. n=6 per group, scale bars: (C) 200 μm. (D) Nrp1 mRNA levels (n=4) and (E) Nrp1 protein expression in DRGs 7 days after addition of MS-SCs-EVs, miR-23b-3p KD MS-SCs-EVs and SCs-EVs in the injury site of rats with sciatic nerve injury. The results are expressed as the mean ± SEM. One-way ANOVA test with Tukey's post hoc test were used to examine the significance of results.* P<0.05 for comparison with the negative control group or the MS-SCs-EVs group.