Table 1.

Roles of the Adolescent and Young Adult Responsible Investigator

Role	Examples
1. Address regulatory issues	Work with research office and IRB to advocate for opening AYA trials Assist medical oncology research offices with navigating cross-enrollment process Ensure adherence with study procedures and reporting of adverse events for AYA cross-enrollments
2. Enhance screening and recruitment processes	Utilize systematic screening processes to identify and target AYA patients for recruitment to front-line, retrieval, and non-therapeutic studies Establish cross-service screening processes with medical oncology to address full AYA age spectrum Designate consistent clinical or research staff member to lead screening efforts (e.g., nurse or clinical research associate) Initiate cross-service email notifications of newly diagnosed AYAs and potentially applicable studies
3. Facilitate collaboration between pediatric and medical oncology	Address common barriers to collaboration Identify and open available AYA eligible trials Form partnerships to identify and recruit AYAs eligible for COG and other NCTN trials Ensure adherence with protocol requirements Facilitate COG membership for medical oncology Form COG-SWOG dyad for COG AYA RI Network, if applicable Establish joint tumor boards, where applicable
4. Serve as the institutional AYA-focused communication link with COG, including the AYA RI Network	Provide site-level feedback for active and proposed COG studies Serve as the recipient of COG accrual updates, newsletters, and surveys Share site-level information on local enrollment challenges and solutions Participate in COG AYA RI Network webinars
5. Raise local awareness and educate regarding AYA clinical trial enrollment disparities	Track local AYA enrollments Share local AYA enrollment figures with medical oncology, nursing, CRAs Present at grand rounds, seminars, tumor boards Educate staff on strategies to overcome barriers to enrollment Disseminate information from AYA RI Network webinars

AYA, adolescents and young adult; COG, Children's Oncology Group; CRAs, clinical research associates; IRB, Institutional Review Board; NCTN, National Clinical Trials Network; RI, Responsible Investigator; SWOG, SWOG Cancer Research Network.