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. 2020 Aug 4;27(8):1204–1218. doi: 10.1089/cmb.2019.0340

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© Zhenghao Chen, et al., 2020. Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 1. — In situ profiling of tissue slices using technologies such as CODEX and MIBI-TOF enable simultaneous spatial measurement of a panel of markers. These markers can be aggregated into cellular phenotype. Counts of cell neighbor's phenotypes are proxies for cell microenvironment.