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. 2020 Aug 4;27(8):1204–1218. doi: 10.1089/cmb.2019.0340

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© Zhenghao Chen, et al., 2020. Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 5. — Tumor sections colored by the “dominant” TME topic (TME topic with the highest weight) for each cell. Note the heterogeneity within the tumor interior and across the mixed tumor samples. Purple corresponds to topic 1, green to topic 2, blue to topic 3, yellow to topic 4, and pink to topic 5. Note the overrepresentation of TME topic 4 in mixed tumors with poor prognosis. (A) Five compartmentalized tumors. (B) Bottom quartile of mixed tumors by predicted hazard. (C) Top quartile of mixed tumors by predicted hazard.