Table 3.

Multivariate Analysis of Parameters Associated with Absolute Changes in TRL Over 4 Years in the 1-mm (Subfoveal), 3-mm, and 6-mm Circles (N = 77)

	Total Retinal Thickness (µm)
Parameter	1-mm Circle	P	3-mm Circle	P	6-mm Circle	P
Age at baseline (y)	0.35 (0.055, 0.65)	0.021	0.12 (−0.073, 0.31)	0.22	0.008 (−0.12, 0.14)	0.90
Male (%)	−1.33 (−5.84, 3.18)	0.56	−1.81 (−4.70, 1.07)	0.21	−1.22 (−3.22, 0.79)	0.23
Smoking status	2.07 (−2.32, 6.46)	0.35	1.24 (−1.56, 4.05)	0.38	0.36 (−1.54, 2.25)	0.71
BCVA baseline	0.66 (0.13, 1.20)	0.016	0.16 (−0.18, 0.50)	0.36	0.020 (−0.21, 0.25)	0.86
Change in BCVA (letters) over 4 y	0.65 (0.17, 0.99)	0.0059	0.30 (0.25, 0.61)	0.027	0.069 (−0.11, 0.25)	0.44
Pseudophakia	−4.55 (−10.20, 1.088)	0.11	−3.93 (−7.53, −0.33)	0.030	−1.48 (−3.94, 0.98)	0.23
Group 1 vs. Group 0	−3.88 (−10.52, 2.75)	0.25	−4.22 (−8.46, −0.013)	0.051	−2.92 (−5.84, −0.0074)	0.049
Group 2 vs. Group 0	−1.90 (−7.65, 3.86)	0.51	−3.57 (−7.24, 0.11)	0.057	−0.89 (−3.39, 1.62)	0.48
Group SDD vs. Group 0	−10.82 (−18.38, −3.25)	0.0058	−11.88 (−16.77, −6.90)	<0.0001	−6.74 (−9.96, 3.51)	<0.0001
Choroid thickness at baseline*	−0.0011 (−0.043, 0.020)	0.48	−0.0016 (−0.022, 0.019)	0.98	−0.00076 (−0.017, 0.015)	0.93
Choroid vascularity index at baseline*	21.43 (−24.49, 67.35)	0.35	3.21 (−26.12, 32.54)	0.83	−4.19 (−29.32, 20.94)	0.74

Values represent estimates with 95% confidence intervals in parentheses. Significant estimates are highlighted in bold.

^*Choroidal features were assessed for TRT in single horizontal scans traversing the fovea across the 1-mm, 3-mm, and 6-mm regions centered on the fovea.