Figure 4.

Global Gene Expression Analysis of LADC Organoids

(A) RNA-seq data of 12 LADC organoid lines were normalized and combined with TCGA RNA-seq data (541 samples). The combined data were clustered using the 500 most-variable genes using 1-correlation distance with complete linkage.

(B) Correlation heatmap of LADC organoids (_O) and tumor tissues (_T) based on RNA-seq expression data. Correlations were calculated for all paired organoids and tumors using all genes (column z-scored).

See also Figure S5.