Table 4.

Conformation of the plug loop based on the crystal structures of l-LOX/MOG with l-lysine, l-ornithine, and l-arginine bound; PAO with l-phenylalanine bound, TMO with IAM bound, l-AAO with l-phenylalanine bound, and MAO B with N-[(E)-methyl](phenyl)-N-[(E)-2-propenylidene]methanaminium (NYP) (MAO B inhibitor) bound

Cα-RMSDs from alignments are shown in comparison with the structure of l-LOX/MOG and l-lysine (5YB6).

PDB	Enzyme	Ligand	Conformation of the plug loop	Product from imino acid		RMSD	Reference
				Decarboxylation	Deamination
						Å
3WE0	l-LOX/MOG		Opened	−	−	0.531	38
5YB6	l-LOX/MOG	l-Lys	Closed	++	+		40
5YB7	l-LOX/MOG	l-Orn	Opened	+	++	0.206	40
5YB8	l-LOX/MOG	l-Arg	Opened	NDa	NDa	0.417	40
3AYJ	PAO	l-Phe	Closed	++	+	4.384	23
4IV9	TMO	IAM	Closed	+++	−	1.177	24, 47
2IID	l-AAO	l-Phe	No plug loop	−	+++	2.525	48
1GOS	MAO B	NYP	No plug loop	−	+++	8.857	49

^aND, not determined.