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. 2020 Jun 9;295(32):11082–11098. doi: 10.1074/jbc.RA119.009981

Figure 2.

Figure 2.

The downregulation of NEIL2 transcript in primary and transformed gastric epithelial cells after H. pylori infection. A, the schematic diagram shows the infection of the primary (Hs738) and transformed (AGS, NCI-N87) cells with H. pylori. B, the expression of NEIL2 transcript was determined by qRT-PCR (qPCR) in AGS cells after H. pylori infection at the indicated time points. C and D, NEIL2 transcript expression was tested in primary Hs738 cells (C) and NCI-N87 cells (D) after H. pylori infection. B–D, the expression of the uninfected control was taken as 1. E, i, the schematic shows the gastric biopsies used in step ii and H. pylori-infected enteroid-derived monolayers (EDMs) used in step iii. ii, NEIL2 expression was detected by qPCR in H. pylori-positive and -negative human gastric biopsy specimens (6 negative and 4 positive). The expression of the H. pylori-negative sample was taken as 1. iii, EDMs from gastric specimens of healthy subjects were infected with H. pylori. Data were generated from the means ± S.D. from three independent experiments. *, p < 0.05.