Figure 5.

The proinflammatory responses in gastric tissue following H. pylori infection depend on NEIL2. A, schematics show the planning of animal experiments with C57-BL/6 mice to isolate RNA and histopathology. B–D, the relative mRNA expressions of IL-8 (KC), TNF-α, and IFN-γ were determined by qRT-PCR of gastric tissues from H. pylori-infected WT and Neil2 KO mice. E, histology scores of stomach specimens of WT mice and Neil2 KO mice before and after H. pylori infection. *, p < 0.05; ***, p < 0.001. F, representative images from the stomach specimens of H. pylori-infected WT and Neil2 KO mouse groups.