1.

Studies showing associations between elevated level of hs-CRP and short- and long-term risks during and following acute myocardial infarction.

Author	Study design, country	Population	Type of risk, condition	Key findings for associations
AMI: acute myocardial infarction; CI: confidence interval; GRACE: Global Registry of Acute Coronary Events score; HR: hazard ratio; hs-CRP: high sensitivity C-reactive protein; NSTEMI: non ST-elevation myocardial infarction; OR: odds ratio; STEMI: ST-elevation myocardial infarction; TIMI: Thrombolysis in Myocardial Infarction risk score; *Adjusted for age, sex, body mass index, and other confounding variables.
Liu, et al.[1]	Prospective, obser- vational study in a single center, China	Patients with AMI, n = 10, 020 Age: 58.1 ± 10.1 yrs 22.7% female	Long-term sign: predicting the number of stenotic coronary arteries	*OR = 1.72 (95% CI: 1.08–2.74); P = 0.022
Karadeniz, et al.[3]	Population study, Turkey	Patients with STEMI and NSTEMI, n = 321 Age: 63 ± 13 yrs	Short-term risk: the strongest predictor of SS	*OR = 1.14 (95% CI: 1.05–1.25); P = 0.002
Mayr, et al.[26]	Population study, Austria	Patients within eight days after first STEMI with PCI, n = 118 Age: 55.7 ± 11.7 yrs, 16.1% female	Short-term sign: infarct size prediction (cardiac magnetic resonance)	Correlation: r = 0.60, P < 0.0001
Yoshizaki, et al.[34]	Prospective observational trial, Japan	Patients with STEMI, n = 259 Age: 74 ± 10 yrs, 25% female	Short-term risk: atrial fibrillation	*Adjusted OR: 1.15 (95% CI: 1.04–1.27)
Kobayashi, et al.[32]	Retrospective observational study, Japan	Patients with STEMI, n = 6033 Age: 74 ± 10 yrs, 25% female	Short-term risk: an independent predictor of in-hospital ventricular tachycardia/fibrillation storm	*Adjusted OR: 1.073 (95% CI: 1.004–1.148); P = 0.039
Raposeiras- Roubín, et al.[23]	Population study, Spain	Patients with AMI, n = 98 Age: 60.0 ± 13.5 yrs, 26.5% female	Short-term risk: a predictor of worse in-hospital outcomes independently of GRACE risk score	*Adjusted OR: 1.122 (95% CI: 1.005–1.252) P = 0.040
Bursi, et al. [41]	Prospective study, USA	Patients with STEMI and NSTEMI, n = 329 Age: 69 ± 16 yrs, 48% female	Long-term risk: a predictor of heart failure and death	*For heart failure adjusted HR: 2.47 (95% CI: 1.27–4.82) *For death Adjusted HR: 3.96 (95% CI: 1.78–8.83)
Ribeiro, et al.[15]	Prospective cohort study, Brazil	Patients with STEMI and NSTEMI, n = 300 Age: 59 ± 11 yrs, 30.7% female	Long-term risk: an independent predictor of 30-day mortality	Adjusted for TIMI, OR: 1.27 (95% CI: 1.07–1.51), P = 0.005 Adjusted for GRACE, OR: 1.26 (95% CI: 1.06–1.49), P = 0.007
Stumpf, et al. [40]	Single-center prospective observational cohort trial, Germany	Patients with STEMI and NSTEMI, n = 81 Age: 69 ± 11 yrs, 31% female	Long-term risk: predicting one-year total mortality and HF mortality	Higher in patients with peak > 47.5 mg/L than in below level (P < 0.001)
Milano, et al. [16]	Retrospective cohort study, Brazil	Patients admitted with STEMI, n = 118 Age: 60 yrs (interquartile range of 19.75 yrs) 30.6% female	Short-term risk: predicting in-hospital mortality	Binary logistic regression analysis. *Adjusted OR = 1.15 (95% CI: 1.06 to 1.28 per unit increase), P = 0.0017
Tello- Montoliu, et al.[35]	Prospective study, Spain and UK	Non-ST ACS patients with 6-months follow-up, n = 358 Age: 67.4 ± 12.4 yrs 35.8% female	Long-term risk: a predictor of adverse events (cardiovascular death, recurrent ACS, nonselective revascularization and /or admission for acute heart failure)	*Adjusted OR: 1.90 (95% CI: 1.24–2.92), P = 0.0034
Suleiman, et al.[36]	Prospective study, Israel	Patients with STEMI, n = 448 Age: 60 ± 12 yrs; 16.1% female	Long-term risk: predicting 30-day mortality and heart failure	*OR: 3.0 (95% CI 1.3–7.2), P = 0.01 *OR: 2.6 (95% CI: 1.5–4.6), P = 0.0006
Yanishi, et al. [37]	AMI-Kyoto registry, Japan	Patients with STEMI, n = 1060 Age: 70.0 ± 12.4 yrs; 29% female	Short-term risk: predicting in-hospital mortality	*Adjusted OR: 2.19 (95% CI: 1.38–3.51)
Ahmed, et al. [21]	Korea AMI registry, Korea	Overweight/obese patients with STEMI and NSTEMI, n = 8174 Age: 62.7 ± 12.4 yrs; 24% female	Long-term risk: predicting all-cause mortality at 12 months	For hs-CRP level ≥ 4.08 mg/dL HR: 2.382 (95% CI: 1.079–5.259), *P = 0.032