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. 2020 Jul 21;2020:9397109. doi: 10.1155/2020/9397109

Figure 2.

Figure 2

Apabetalone downregulates cytokine-induced expression of APR genes in hepatocytes. (a, b) Apabetalone (25 μM) reduces IL-6 mediated induction (72 h) of CRP, A2M, and APCS mRNA (rtPCR) (a) and protein (ELISA) (b). Data is presented as the mean ± S.D. (c, d) Apabetalone (25 μM) reduces IL-1β-mediated induction of CRP mRNA (c) and protein (d). Data is presented as the mean ± S.D. (e) Hepatic APR gene expression is downregulated by apabetalone in the LPS mouse model of systemic inflammation (rtPCR, 24 h post-LPS injection). (f) Innate immune gene expression in mouse liver (real-time PCR, 24 h post-LPS injection). (e, f) Data acquired from 6 to 8 animals per group and presented as a mean ± S.E.M. normalized to naïve mice. Statistical significance was determined through 1-way ANOVA analysis followed by Tukey's multiple comparison test, where ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ns means nonsignificant.