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Losartan reduces the cytokine secretions of IL-1β, IL-8, MCP-1, TNF-α, IL-1RA, IL-6, and VEGF from cocultures of healthy control monocytes with MSCs after 24 hours of exposure, while decreasing only IL-8 secretions from cocultures involving stoke patient-derived monocytes without changing any other cytokine secretions. Significance is shown by ∗p < 0.05. All fold changes are as compared to vehicle control.
