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. 2020 Jun 3;176(2):343–354. doi: 10.1093/toxsci/kfaa081

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Published by Oxford University Press on behalf of the Society of Toxicology 2020. This work is written by US Government employees and is in the public domain in the US.

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Figure 2. — Lowest liver transcriptional versus apical benchmark doses (BMDs) in male rats. The fold difference of the lowest liver transcriptional Gene Ontology Biological Process (GO BP) BMD and the lowest apical (non-neoplastic [A] or neoplastic [B]) BMD is shown in male rats. A negative fold difference indicates that the liver GO BP BMD is less than the apical (non-neoplastic or neoplastic) BMD. A positive fold difference indicates that the liver GO BP BMD is greater than the apical (non-neoplastic or neoplastic) BMD. The solid line represents no difference, whereas the dotted lines represent a 10-fold difference between the liver GO BP BMD and the apical (non-neoplastic or neoplastic) BMD. HT indicates hepatotoxic chemicals. Non-HT indicates chemicals that exhibit minimal/no hepatotoxicity but produce adverse effects in other tissues.