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. 2020 Jun 3;176(2):343–354. doi: 10.1093/toxsci/kfaa081

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Published by Oxford University Press on behalf of the Society of Toxicology 2020. This work is written by US Government employees and is in the public domain in the US.

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Figure 5. — Lowest transcriptional (liver or kidney) versus apical (non-neoplastic or neoplastic) benchmark doses (BMDs) for different sex and species. The fold difference of the lowest transcriptional Gene Ontology Biological Process (GO BP) BMD (liver or kidney) in male rats and the lowest apical (non-neoplastic or neoplastic) BMD in female rats (A), male mice (B), and female mice (C) is shown. A negative fold difference indicates that the liver or kidney GO BP BMD is less than the apical (non-neoplastic or neoplastic) BMD. A positive fold difference indicates that the liver or kidney GO BP BMD is greater than the apical (non-neoplastic or neoplastic) BMD. The solid line represents no difference, whereas the dotted lines represent a 10-fold difference between the liver or kidney GO BP BMD and the apical (non-neoplastic or neoplastic) BMD. HT indicates hepatotoxic chemicals. Non-HT indicates chemicals that exhibit minimal/no hepatotoxicity but produce adverse effects in other tissues. Neg indicates chemicals that exhibit little overt toxicity to the liver or other tissues. PFOA (−353-fold) is not shown on the graph in A for female rats due to scaling.